Natural Sleep & Calm Support
Melatonin is a hormone naturally produced in a dog's pineal gland that helps regulate the body’s internal clock, also known as the circadian rhythm. When used as a supplement, melatonin for dogs may help support more consistent sleep patterns, making it especially helpful for pets that experience nighttime restlessness or difficulty settling down.
*or as needed
Frequently Purchased Together
Commonly added with Melatonin for Dogs
Third-Party Trusted Reviews. Real Customers. Real Results.
Overall rating: 4.869565 / 5 from 23 reviews.
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"My senior chihuahua has anxiety and PTSD issues from seeing me go out in an ambulance SO many times,and her vet suggested Melatonin--- WHAT A DIFFERENCE !!! If she starts getting over anxious, I just give her one Melatonin soft chew and in about am hour she's calm She's 13yrs old,so whatever I can do to help her stay calm & comfortable, I'm going to do it,bevause she deserves it !!!"
"Love this product for my cockapoo"
"My five-year-old mixed-breed mutt has pretty strong drug resistance and rebound anxiety. She's also TERRIFIED of fireworks and thunderstorms, and I had never found a truly successful way to help her, and even CBD didn't alleviate her panic. This fourth of July was the first time I tried the Holista melatonin supplements for her fireworks anxiety. I gave her one dose in the late afternoon, and four hours later gave her another dose. Although she wasn't able to fall asleep until close to midnight, unlike with any other treatment attempts, the melatonin actually seemed to keep her pretty calm! She went through the entire night (with explosions literally all around us) WITHOUT panting, pacing, whining, barking, shaking, crawling under the bed, and otherwise exhibiting the kind of panic that has made me concerned that she will have a heart attack. She ate her dinner, drank water. And even slept in her own, uncovered bed--not UNDER my bed or in her crate--while fireworks boomed all around us. I'm so grateful to have a solution--and the fact that it isn't big pharma is even better. THANK YOU Holistapet!"
"THIS PRODUCT HAS BEEN A LIFE SAVER IN HELPING MY SENIOR DOG WITH ANXIETY REST PEACEFULLY AT NIGHT. SHE NO LONGER GETS UP IN THE MIDDLE OF THE NIGHT WITH ANXIETY ATTACKS. PLUS SHE LOVES THE TASTE AND LOOKS AT THEM LIKE THEY ARE A BEDTIME SNACK. WELL WORTH BUYING THIS PRODUCT."
"CBD soft calming chews works great for my 15 year old dog!"
"........with some adjustments. I've ordered this before, but my Yorkie (with no teeth) wouldn't take them. We baked them (to dehydrate the treats), then ground them up and mixed the powder with chicken broth. Then put it in a syringe and he took it like a champ. Maybe Holistapet could engineer a similar product and market it as liquid Melatonin."
"I needed to contact customer service because of my own lack of technology skills and was greeted by such a kind and helpful person. My dogs love their Holistapet chews and I love purchasing them from a company that offers such excellent customer support."
"Works wonderfully!"
"Great product. Works. German Shepherd and Akita approved"
"Melatonin for Dogs"
Our Melatonin for Dogs is formulated with carefully selected ingredients designed to support relaxation and healthy nighttime rest in dogs.
Melatonin plays an important role in regulating biological rhythms in both humans and animals. Research shows that this naturally occurring hormone helps control sleep-wake cycles, which are influenced by light exposure and internal circadian timing mechanisms. In dogs, balanced melatonin activity may support calm nighttime behavior and general relaxation.
Buy Melatonin Soft ChewsResearchers studying melatonin in animals have observed that the hormone plays a central role in regulating circadian rhythms and sleep timing. A review published in the Journal of Animal Science and Technology discusses how melatonin helps synchronize biological clocks in mammals and may influence sleep cycles in companion animals. Understanding this regulatory function helps explain why melatonin supplements are sometimes used to support nighttime calmness in dogs.
Veterinary behavioral research has examined how melatonin may influence stress responses in animals. Some studies suggest that the hormone may help regulate neurochemical pathways involved in calm behavior and environmental adaptation. Researchers continue to investigate melatonin’s role in supporting animals during periods of environmental change or temporary stress.
Several veterinary studies have explored pet melatonin supplementation in dogs experiencing seasonal flank alopecia, a condition linked to hormonal cycles. Research published in veterinary dermatology journals suggests that melatonin may support hair regrowth in some dogs affected by seasonal hair loss. These findings highlight melatonin’s role in hormonal regulation within the canine body.
Melatonin has also been studied for its interaction with endocrine functions in animals. Research published through the Journal of Veterinary Behavior describes how melatonin interacts with hormones that influence seasonal biological changes in mammals. This research provides insight into how melatonin may support normal physiological rhythms in dogs.
Dr. Kwane Stewart is a licensed veterinarian and HolistaPet’s Chief Veterinary Advisor with decades of experience caring for animals. He provides veterinary guidance on product development and reviews product-related educational content to support accurate pet wellness information. His involvement helps ensure HolistaPet’s products and resources reflect responsible, science-informed practices for pet owners. Beyond his role with HolistaPet, Dr. Stewart is also the founder of the nonprofit Street Vet initiative, which provides veterinary care to pets belonging to individuals experiencing homelessness. Learn more about Dr. Kwane Stewart here.
Veterinary expertise plays an important role in developing and reviewing dog wellness supplements. Guidance from experienced veterinarians helps ensure that ingredients, nutrient levels, and formulations are appropriate for canine health and safety. At HolistaPet, Dr. Kwane Stewart serves as Chief Veterinary Advisor. His veterinary perspective helps ensure that our product formulations and wellness resources align with current understanding of canine nutrition and health.
Active Ingredients:
Inactive Ingredients: Acacia Gum, Blackstrap Molasses, Calcium Propionate, Chickpea Flour, Flax Oil, Glycerin, Mixed Tocopherols, Nutritional Yeast, Natural Smoke Flavor, Rosemary Extract, Safflower Oil, Sorbic Acid, Sunflower Lecithin, Sweet Potato, Tapioca Starch, Water.
Yes, dogs can take melatonin, and it is sometimes used in veterinary medicine to support healthy sleep patterns and calm behavior. Melatonin is a natural hormone that regulates the body’s sleep-wake cycle, and veterinarians may recommend it for dogs experiencing sleep disorders, nighttime restlessness, or temporary stress. Because dogs naturally produce melatonin, small supplemental amounts can help support normal circadian rhythms.
Melatonin may begin supporting calm behavior within about 20–60 minutes after administration. Because it works with the body’s natural sleep-wake signals, it is often given before bedtime or before potentially stressful situations. The calming effects typically last 4–8 hours, depending on the dog’s size, metabolism, and sensitivity to the supplement.
Melatonin is typically given in the evening to support healthy nighttime sleep cycles. Some pet owners also give melatonin before situations that may cause temporary stress, such as travel or changes in routine. Providing the supplement around the same time each day can help maintain a consistent circadian rhythm.
We recommend giving your dog our Calming Melatonin Soft Chews once a day or as needed. Here are the recommended serving suggestions based on your dog’s weight:
Less than 20 lbs = 1 chew*
20–50 lbs = 2 chews*
More than 50 lbs = 3 chews*
*or as needed
Always follow product serving guidelines and consult your veterinarian if you have questions about your dog’s individual needs.
Melatonin is generally well tolerated by dogs, but mild side effects can occasionally occur. These may include temporary drowsiness, digestive upset, or slight changes in energy levels. Research indicates melatonin has a relatively wide safety margin in mammals, but proper dosage is important. Pet-specific supplements formulated with safe ingredient levels help reduce the risk of unwanted reactions.
Yes, dogs can have too much melatonin if given higher amounts than recommended. Excess melatonin may cause mild side effects such as drowsiness, digestive upset, or changes in energy levels. Always follow the serving guidelines on pet-specific supplements and consult a veterinarian if you’re unsure about proper dosing.
Melatonin may interact with certain medications, so it’s important to check with a veterinarian before giving it to your dog. Potential drug interactions could occur with medications that affect hormones, sedation, or blood pressure. A veterinarian can help determine whether melatonin is appropriate for your dog’s current health routine.
